The team qualified by winning the regional trials in November and represent London against the East, North West, Wales, East Midlands, South East, South West and Yorkshire/Humberside at the University of Bath.
Karolina Rapacka, Danni Albertsen, Lauren Picton, Kyra Irons, Faye Picton, Courtney Miller, Ayse Mustafa, Louise Bennett, Sophie McLean and Danni Crafton-Brown will travel to Bath.
Danni and Lauren were both in the Tottenham Hotspur Ladies squad for Sunday's 2-2 draw against QPR in the FA Women's Premier League. Danni, just 16, came on in the 15th minute for injured Davina Smith.
This is the first time since 1994 that London has been its own region, and therefore the students will be the first representatives of the London Region at the Nationals since its formation.
The National Championships involves more than 2,500 students and staff from further education colleges across England, Scotland and Wales competing in 14 different sports.
Regions collate points across all sports and the overall winner is presented with the prestigious Wilkinson Sword, won by the South West last year.
The Tottenham Hotspur Foundation runs Development Centres in partnership with Barnet & Southgate College, St Thomas More College and Waltham Forest College.
They give young people classified as NEET (Not in Education, Employment or Training) the opportunity to re-engage with Further Education via the hook of playing representative football for their college and receiving Academy-standard coaching from Tottenham Hotspur.
The Education and Football Development Centre scheme was shortlisted for a prestigious Sport Industry Award in 2012.