Andros Townsend and Danny Rose are both doubtful for Sunday's Premier League clash at Hull.
Mauricio Pochettino also reported concerns over other players after Friday’s training session.
Andros was forced to withdraw from international duty with an ankle injury while Danny suffered a rib injury in the final minutes last time out against Stoke on November 9.
“We have another training session tomorrow to review and test some players and then we will decide the squad that travels to Hull,” said Mauricio.
Kyle Naughton misses out as he serves a two-match suspension after picking up a red card against Stoke.
There was better news about Kyle Walker, now back in training after abdominal surgery and Nabil Bentaleb, who is recovering from an ankle injury.
“Kyle is getting better and maybe if he follows in the same way it’s possible he might start to play again in the next few weeks,” added Mauricio.
“Nabil is the same as Kyle, getting better, not fully recovered yet but now looking to be involved in training.”