The German international missed last week's reserve clash at Ipswich Town but joins Kazu Toda, Stephane Dalmat and Bobby Zamora in the side to take on the Saints at St Marys.
Colin Calderwood's men have played well without reward in recent meetings at St Marys and coach Colin hopes to set the record straight this time around.
He believes playing at the main stadium will lift the lads. "It's similar to last week when we went to Portman Road and I've no doubt that lifted our performance," said Colin.
"We've never won there despite playing well but we've got a decent team out again and we're looking forward to it.
"Southampton have had a decent start to the reserve league and are right up there with Charlton and Chelsea and their youth team's doing well in the U19 league.
"They are strong and tend to play anyone who isn't in the first team."
Squad: Hirschfeld, Marney, Ziege, Henry, O'Donoghue, Hughes, Toda, Dalmat, Jackson, Zamora, Yeates, Barnard, Slabber, Barnett, Eyre.
Christian Ziege continues his comeback with a return to reserve team action at Southampton tonight.