Hugo Lloris will lead France against Ukraine, Vlad Chiriches and Romania take on Greece while Gylfi Sigurdsson and Iceland take on Croatia. The fourth match sees Portugal meet Sweden.
The four winners of the play-offs go into the finals in Brazil.
PLAY-OFF DRAW - home teams to play first leg at home
Portugal v Sweden
Ukraine v France
Greece v Romania
Iceland v Croatia
First legs played on Friday, November 15
Second legs played on Tuesday, November 19