Mauricio Pochettino’s men are 5/1 to come away with all three points while the draw is priced at 63/20.
The Red Devils have only beaten Spurs once in their last six league meetings and Spurs are 109/50 to score first.
Spurs have led at half time in two of their previous three matches at Old Trafford and a similar outcome is available at 51/10
After scoring 21 league goals last season Harry Kane will hope to continue from where he left off and could be worth backing to score anytime at 9/5 - or 33/5 to score first in the match.
Find out more Manchester United vs Spurs odds at Marathonbet.co.uk...