Tom Carroll is in the squad after his fine recent performance for the first team against NK Maribor and he's joined by the likes of Ryan Fredericks, Yago Falque, Massimo Luongo, Ryan Mason and Jon Obika.
The team has surged to the top of Group Two of the Barclays U21 Premier League with a string of fine performances - and goals galore.
They hit top spot with a magnificent 6-0 win against Newcastle last time out - that made it four wins in five, three on the trot and 31 goals so far in eight games!
There was plenty of goal action the last time the Under-21s played at the Lane - a 3-3 draw against Villa - and now they face a Southampton team who they beat 4-2 away in October.
• Juniors and Senior Citizens: £1
• Adult Members: £3
• Adults: £5
Call the Ticket Office on 0844 844 0102 (option 2) or visit the Ticket Office, Monday-Friday, 9.30am-5pm.
Fans can pay on the night - head to the West Stand Lower turnstiles.