The match takes place at the Salford City Stadium, home of Sale Sharks and Salford City Reds and kicks-off at 7pm.
The lads currently top the Elite Group of the Barclays U21 Premier League.
Indeed, United's win against Southampton means the team have already secured a place in the play-offs.
Only Liverpool - currently second - and United, now third, can catch us.
The top three from the Elite Group go into the play-offs with the final semi-final place decided by a play-off between the winners of Group One and Group Two.
So the next challenge is for the team to win the Elite Group - five points from the remaining matches against United, Arsenal and Southampton would do it.
Monday's 1-1 draw at West Ham means the team have lost just twice in their last 21 fixtures and they top the Elite Group with eight wins and two draws from 11 games.
Entry is free at the Salford City Stadium. Travelling fans are advised to use the postcode M30 7LJ in satnavs.