Sidelined by an ankle injury since October, Edwards was joined in the starting line-up by Cameron Carter-Vickers and Josh Onomah, both making their first appearances in the Premier League 2 this season.
Things started so well against the third-placed Reds.
Edwards opened the scoring on 18 minutes with a fine low strike from the right angle, bending the ball into the bottom corner with his left foot.
It was soon 2-0 as Nathan Oduwa won possession and the ball eventually fell for Will Miller, who finished despite the efforts of goalkeeper Kamil Grabara and Joe Gomez on the line.
The next goal was always going to be key and Liverpool got a foot back in the game after Joe Muscatt clipped Trent Alexander-Arnold in the box and Harry Wilson converted from the spot.
Liverpool levelled via Sheyi Ojo's curler just two minutes into the second half and had their best spell after that, but it looked like we'd hold out for a draw until Kevin Stewart timed his run to perfection to meet Alexander-Arnold's cross and bury the winner eight minutes from time.
GOAL: LIVERPOOL 0-1 SPURS - MARCUS EDWARDS - 18mins
The game promised to be open from the start and after a decent effort at each end - Rhian Brewster volleyed just over, Grabara saved well from Shilow Tracey - we took the lead on 18 minutes. After a good move, Kyle Walker-Peters got to the right byline, his cross was blocked but the ball fell to Edwards, who hit a powerful, low curler into the far corner.
GOAL: LIVERPOOL 0-2 SPURS - WILL MILLER - 25mins
Oduwa won possession in Liverpool's right-back area, darted into the box and squared for Tracey, his shot was blocked but Will Miller was on the scene first and his effort found the net despite the best efforts of Grabara and Gomez back on the line.
GOAL: LIVERPOOL 1-2 SPURS - HARRY WILSON (PEN) - 28mins
Alexander-Arnold broke into the box from the right, went over Muscatt's challenge and the officials agreed on a penalty. Wilson made no mistake from the spot, driving low into the corner. Goalkeeper Tom Glover then saved well from Ben Woodburn's free-kick on 40 minutes.
Above: Josh Onomah in action.
GOAL: LIVERPOOL 2-2 SPURS - SHEYI OJO - 47mins
Liverpool came quickly out of the traps after the break and levelled two minutes into the second half. The angle looked to be against Ojo in the right channel of the box but the winger curled across Glover into the far corner.
PRESSURE: LIVERPOOL'S BEST SPELL - 46-67mins
Buoyed by the equaliser, Liverpool pinned us back for 20 minutes. Matt Virtue's shot deflected just wide, Corey Whelan's header was kept out by a combination of Muscatt and the post, Virtue blasted wide from the left angle, Connor Randall drove into the box from the left and placed his effort just wide and Stewart connected with a half-volley from 30 yards that whistled just wide.
GOAL: LIVERPOOL 3-2 SPURS - KEVIN STEWART - 82mins
Just at it looked like we'd weathered the storm, Alexander-Arnold found a fine cross from a tight position on the right, headed away by Carter-Vickers. Liverpool took the corner quickly back to Alexander-Arnold and his cross was met by ex-Spur Stewart driving into the box and his header from eight yards flew in.
LAST CHANCE: ODUWA'S HEADER SAVED - 90+3mins
We kept going until the final whistle and almost found an equaliser in the last action as Oduwa rose well to meet a corner at the far post but couldn't generate enough power on his header to beat Grabara.
COACH UGO EHIOGU SAID
"It's disappointing when you score two goals away from home and end up losing 3-2, that's a massive momentum change in a game. We started well but then switched off, allowed them to have a spell of pressure, conceded a penalty and that's the game-changer. We weathered that and although we were still a little ruffled, when we played quickly, bravely and one-touch forward, we were able to cut them open but we didn't see enough of that today. It's frustrating, the ups and downs. It would have been nice to hang on and get a point but it wasn't to be. There is a lot to work on but we'll get this out of our system and try to be better next time.
"I thought Luke Amos epitomised spirit, tenacity, never giving up and there was an assurance about him today on the ball. We'd like to thank Southend (Luke's loan club) and Burton Albion (Will Miller's loan club) for making Luke and Will available, they've been first-class and we value that relationship. Marcus Edwards scored a good goal and came through unscathed, so that's another positive."
Liverpool: Grabara, Alexander-Arnold, Randall, Gomez, Whelan, Stewart, Wilson (c), Virtue (Williams 83), Brewster, Woodburn, Ojo. Substitutes (not used): Alves, Hart, Gomes, Kelleher (GK).
Spurs: Glover, Walker-Peters, Lesniak (c), Carter-Vickers, Muscatt, Amos, Miller (Marsh 56), Edwards (Pritchard 59), Onomah (Goddard 89), Oduwa, Tracey. Substitutes (not used): Maghoma, McDermott (GK).
Goals: Liverpool - Wilson 28 (pen), Ojo 47, Stewart 82; Spurs - Edwards 18, Miller 25.
Yellow cards: Spurs - Marsh 74.
Referee: Andrew Miller.
We take on Sunderland in the Premier League 2 at Stevenage on Monday, February 20.