Harry Kane led the way with a hat-trick with further goals from Tom Carroll, Yago Falque and Andros Townsend as the team made it two out of two in the Barclays U21 PL - 4-2 at Chelsea and now 6-3 against City.
Next up, West Ham at Upton Park this Friday, 7pm.
Spurs U21s: Archer; A McQueen (Coulthirst, 78), Ball, Stewart, Fryers; Bentaleb, Carroll, Sandro (Dombaxe, 67); Falque, Kane, Townsend. Unused subs: Miles, Gallifuoco.
Manchester City: Gunn, Drury, Leigh, Deneyer, Bossaerts, Evans, Bytyqi, Hutton, Hiwula (Bunn, 63), Lopes (Glendon, 53), Ntcham. Unused subs: Lawlor, Huws, Plummer.
Goals: Spurs - Carroll (3), Kane (35, 55, 64), Falque (53), Coulthirst (90+2). City - Lopes (44), Bunn (70), Glendon (79).