The Toffees took an 80th-minute lead at Southport FC's Merseyrail Community Stadium as Liam Walsh finished off a counter-attack, but Andros Townsend restored parity from the penalty spot three minutes later after substitute Emmanuel Sonupe was brought down in the box.
Everton U21s: Hewelt, Connolly (Walsh 75), Foulds, Davies, Thorniley, Holgate, Charsley, Williams, Byrne (Dowell 62), Rodriguez (Evans 69), McAleny. Substitutes (not used): Dyson, Gray (GK).
Spurs U21s: Voss, Walker-Peters, Amos, Lesniak, Carter-Vickers, Veljkovic (c), Townsend, Winks (Miller 77), Coulthirst, Walkes, Georgiou (Sonupe 69). Substitutes (not used): Hayford, McDermott (GK).