As a result, the nearby Seven Sisters and Tottenham Hale tube stations will be closed after the Worthington Cup tie against Cardiff City.
Over ground trains will be running from White Hart Lane and Northumberland Park. Bus services along the High Road will not be affected.
The club would advise fans travelling by car to arrive earlier than normal where possible as it is expected more fans will travel this way because of the strike action.
Supporters are reminded that London Underground trains will stop running at 8pm on Tuesday night due to strike action.