The line through White Hart Lane and between Waltham Cross and Broxbourne is closed until 10.55am.
Fans travelling earlier for the 12noon kick-off against United may therefore find that part of their journey involves a rail replacement service.
An intense service is planned from 10.55am at both White Hart Lane and Northumberland Park until kick-off.
The first direct trains to White Hart Lane will be:
10.40am Hertford East to Liverpool Street - arrives Broxbourne (10.58am), Cheshunt (11.03am), White Hart Lane (11.17am).
10.50am Liverpool St to Enfield Town - arrives Seven Sisters 11.03am, White Hart Lane 11.06am.
10.57am Enfield Town to Liverpool St - arrives White Hart Lane 11.07am.
The first trains to Northumberland Park will be:
9.40am Liverpool St to Cambridge - arrives Tottenham Hale 09.58am and Northumberland Park 10.01am.
10.29am Bishops Stortford to Liverpool St - arrives Harlow Town 10.40am, Broxbourne 10.55am, Cheshunt 10.59am, Northumberland Park 11.13am.
All trains at White Hart Lane and Northumberland Park prior to the game are planned to be eight carriages, as are all trains for two to three hours after the game.
After the game there is an increased frequency from White Hart Lane and Northumberland Park towards Liverpool Street (up to six trains per hour).
There are also additional services from White Hart Lane to Enfield Town, Cheshunt, Broxbourne and Hertford East, and from Northumberland Park to Cheshunt, Broxbourne, Harlow Town, Bishops Stortford and Cambridge.
An amended timetable can be found on the Great Anglia website - to greateranglia.co.uk/travel-information/journey-planning/service-alterations