The convincing win was no less than the team deserved after completely dominating the first half at QPR's Uxbridge home.
Indeed, Spurs struck the woodwork three times and forced QPR goalkeeper into a series of fine saves before Nikita Whinnett finally broke through just before half-time. Whinnett added a second after the break and was joined on the scoresheet by Kelley Blanchflower and Josie Green.
"It was just about keeping our patience and trusting that we'd find the breakthrough," said manager Karen Hills. "We stuck to our game plan, kept playing and once we scored the first goal I was always confident we'd go on to win.
"We look strong at the moment, confident and dangerous going forward. The players can't wait for the next game."
That game is Lewes away in the FAWPL on Sunday (2pm).
QPR 0-4 SPURS LADIES
FA Women's Premier League South
Report by Khalid Karimullah at Uxbridge FC
Photographs - with thanks to Wu's Photography
Tottenham Hotspur Ladies continued their ruthless start to the season after finding the net four times against QPR in a game which saw an impressive attacking display from start to finish.
It was all Spurs from the first whistle with the woodwork and home goalkeeper Sophie Cheadle standing between them and an avalanche of goals.
Nikita Whinnett went close twice early on before Alex Keown's effort from Eartha Pond's corner was cleared off the line by Ellie Searle. Bianca Baptiste hit the post before Kelley Blanchflower and Whinnet set-up Baptiste to slot home, but the flag was up.
Spurs continued to dominate. Sophie McLean's piledriver hit the crossbar and Pond was also denied by the woodwork. Cheadle kept out Baptiste, Mariko Engels cleared off the line from Blanchflower and Cheadle was there again to thwart Whinnett.
Karen Hill's team could have been forgiven for thinking it was 'one of those nights' but their reward arrived just before half-time as Blanchflower set up the opening goal for Whinnett.
Below: Josie Green in action at QPR - photo: Wu's Photography
The pattern continued in the second half as Blanchflower was denied at close range and Whinnett's floated strike hit the crossbar.
There was no stopping Whinnett moments later though as Blanchflower's shot was saved only for Whinnett to pounce on the loose ball for 2-0, 56 minutes on the clock.
Shannon Moloney was next to fire just wide before Blanchflower's display was rewarded with a goal, Alex Keown's effort from Pond's free-kick landed at her feet and she did the rest from close range.
It was certainly a case of saving the best until last as Josie Green picked up the ball centrally and rifled home from 25 yards.
Spurs Ladies: Toni-Anne Wayne, Shannon Moloney, Alex Keown, Jennas Schillaci (Maya Vio 73), Earth Pond, Josie Green, Sophie McLean, Riana Soobadoo (Cheryl Williams 62), Kelley Blanchflower (Wendy Martin 68), Bianca Baptiste, Nikita Whinnett. Subs (unsed): Megen Lynch, Lucia Leon.