Luke Young will hope to kick it all off with a place in the England Under 21 side to face Georgia at Midldesbrough's Riverside Stadium on Thursday.
On Friday both Simon Davies and Gary Doherty are on their travels in the European Under 21 Championship qualifying stages. Davies faces a long trip to Belarus with Wales while Doherty is closer to home in Holland with the Republic of Ireland.
The first round of World Cup qualifying matches take over on Saturday. Stephen Carr is expected to start for Republic of Ireland in a tricky but attractive opener in Holland - it looks between him and Leeds' Gary Kelly for the right-back spot.
Oyvind Leonhardsen is back in the Norwegian squad after missing out on the European Championships this summer. He joins team-mate Steffen Iversen for the home match against Armenia.
Sergei Rebrov goes home again when Ukraine take on Poland while goalkeeper Neil Sullivan should hold onto his number one jersey for Scotland in Latvia.
There is also a high-profile friendly on Saturday with Sol Campbell and Darren Anderton in the England squad to face World and European champions France in Paris on Saturday.
It's a busy international week for us as players jet off to all corners of Europe.