The striker has not recovered fully from an Achilles problem and has not been named in Glenn Hoddle's squad for the big kick-off.
Better news sees Darren Anderton included, he had also been suffering Achilles problems while Ledley King has recovered from a twisted ankle he sustained in last weekend's friendly against AEK Athens.
As predicted, Stephen Carr (knee), Tim Sherwood and Oyvind Leonhardsen (both ankle) are all missing.
Squad: Sullivan, Doherty, Bunjevcevic, King, Ziege, Taricco, Freund, Clemence, Poyet, Ferdinand, Rebrov, Keller, Perry, Davies, Anderton, Iversen, Piercy, Thelwell.
Teddy Sheringham will not lead us out against Aston Villa in Saturday's Premiership opener.