Tom Huddlestone is back in the squad - but Harry Redknapp faces defensive problems at Wigan on Saturday.
William Gallas (knee) has joined Jonathan Woodgate (calf), Ledley King (groin) and Younes Kaboul (thigh) on the sidelines.
The manager also revealed on Friday morning that Gareth Bale (hamstring) would not make the trip to the DW Stadium.
"Gareth isn't fit for tomorrow and William's knee is giving him problems at the moment," said Harry.
Asked about their respective chances of facing Real Madrid in the Champions League on Tuesday, Harry added: "We'll have to wait and see.
"Gareth's hamstring is still tight and you can never tell with a hamstring injury, until you really push it, you are not sure. William is struggling at the moment.
"But Wigan is all-important for us and we can't look to Tuesday yet.
"We've got to do our best to get into the top four again this season. That's our aim, to make it into the Champions League again next season.
"That means we've got to keep picking up points and it's a vital game at Wigan.
"So if Gareth was fit, I'd play him at Wigan. But he's not available."
Tom is back in the squad for the first time since November after recovering from an ankle injury. He came through 80 minutes of a Spurs XI friendly on Tuesday.
Sebastien Bassong looks set to step back into the team alongside Michael Dawson in central defence.
"Seb's not really had a run this season so this is an opportunity for him to play and regain his place in the team," added Harry.