Harry Redknapp will hand debuts to Scott Parker and Emmanuel Adebayor at Wolves on Saturday.
The latest arrivals in the summer transfer window have trained with a full squad of their new team-mates for the first time this week after the international break.
They will now step out as Spurs players for the first time in the Premier League clash at Molineux.
"Scott is ready to play and Emmanuel is short of games, but he's a naturally fit guy and again, ready to play," reported Harry at the training ground on Friday morning.
"They've both trained with us now and it's given us a big lift to have them here."
There was further positive news on Ledley King (knee) and Rafa van der Vaart (hamstring).
"Ledley has an outside chance of playing at Wolves," revealed Harry. "And Rafa's coming on well."
Harry still has a number of injuries to contend with ahead of a difficult trip to the Black Country.
"Sandro (knee) isn't fit and Steven Pienaar (groin) isn't available," added the manager. "William Gallas (calf) will also be another couple of weeks.
"But Niko Kranjcar played in the week for Croatia and came through okay, so that was good, and the other internationals all came back okay."