Both could make their debuts - Mido as a fully-fledged Spurs player following his permanent transfer - with striker Dimitar Berbatov and full-back Lee Young-Pyo both missing.
Dimitar has failed to overcome a groin injury sustained on international duty for Bulgaria while Young-Pyo has been rested having only returned from Asia Cup duty with South Korea on Thursday.
That's the case for Teemu Tainio as well - the midfielder is rested having played 90-minute stints for Finland against Poland and Portugal.
Steed Malbranque is expected to be out for up to eight weeks following a hernia operation.
The good news sees skipper Ledley back in contention following minor knee surgery at the end of July.
Boss Martin Jol reported after training on Friday: "Dimitar still has a groin problem and won't be available, hopefully he'll be available next week.
"Ledley King is back, he's fit and trained today, so there is no problem with him.
"Young-Pyo is back from Korea, he played two games so he's not involved as he only returned on Thursday. Teemu also played two games for Finland, so we'll rest him.
"Pascal Chimbonda is in the squad, Mido is in the squad and so is Jermain Defoe - he played 90 minutes twice for England but he looked fit today."
Mido and Pascal Chimbonda join the returning Ledley King in the squad for Saturday's clash at Manchester United.