Harry Redknapp reports that Rafael van der Vaart is out of Saturday's trip to Bolton and Aaron Lennon a big doubt.
Rafa limped off at Old Trafford with a hamstring problem last weekend but recovered in time to start against Inter Milan on Tuesday.
He scored the opening goal in the 18th minute of our 3-1 win against the European champions but only lasted until half-time.
Meanwhile, Aaron picked up a hamstring injury in training on Thursday.
"Rafa's not fit and Aaron is struggling for Bolton, he has to be doubtful," said Harry.
Ledley King (groin), Michael Dawson (ankle) and Jermain Defoe (ankle) also remain out.
"There's a little group of them - van der Vaart, Lennon, Dawson, Defoe, King, five not-bad players, when you think about it..." added Harry.
"Michael is working as hard as you'd expect. He's improving but he's still a way away and it's the same with Ledley and Jermain.
"They are not fit but whoever has come in and played has done a fantastic job for us."
Heurelho Gomes is available again after being suspended against Inter.