The midfielder will be sidelined for another 10 days after picking up a knee injury in last Friday's defeat against Manchester City.
Dean Richards is also a doubt after his back problem forced him off with 10 minutes left at West Brom on Monday.
Jamie Redknapp is unlikely to feature despite making his comeback for the reserves on Wednesday after five months out with a stress fracture of the foot.
Christian Ziege is training again after a knee ligament tweak but remains out alongside Gary Doherty, also sidelined by a knee problem.
Boss Glenn Hoddle explained this afternoon: "The downside for us this week is Darren. We lost him before West Brom and he'll be out for about 10 days with a knee ligament problem.
"Jamie had 65 minutes for the reserves and there have been suggestions that he'll come back but I've spoken to Jamie today and after five months, he just needs more football.
"It's coming to the end of the season so whether we can get him back for the last game or last two games I don't know yet. I was just happy to see him back out there in a Spurs shirt."
Darren Anderton is out of Sunday's Premiership cracker against Manchester United.