Ledley King and Alan Hutton have been ruled out of Saturday's Barclays Premier League clash with Hull City.
Defender Ledley complained of knee pain on Friday, while right-back Alan is currently suffering from a tight groin.
Benoit Assou-Ekotto, Carlo Cudicini, Aaron Lennon and Jonathan Woodgate all remain sidelined for the visit of the Tigers but continue their recoveries from respective injuries.
Left-back Benoit has been out with a hip injury since last month's win over West Ham but has started running again this week.
Aaron also picked up a groin injury in that match but has made progress in his recovery this week in an attempt to be fit for next Saturday's FA Cup tie with hometown club Leeds United.
Manager Harry Redknapp said on Friday: "He's working hard and running well but only he knows how it feels. He would obviously love to play against Leeds and that's what he's aiming for if it's possible."
Longer-term absentees Carlo (wrist and pelvis) and ‘Woody' (groin) continue their rehabilitation, while striker Roman Pavlyuchenko is back in training after groin trouble earlier in the week.