Lars Hirschfeld (hamstring), Christian Ziege (thigh), Ledley King (ankle), Dean Richards (Achilles), Darren Anderton (knee), Kazuyuki Toda (calf), Jonathan Blondel (broken finger) and new recruit Fredi Kanoute (abductor strain) are on the casualty list.
Better news sees the return to the squad of striker Zamora and goalkeeper Neil Sullivan after a shoulder injury.
Boss Glenn Hoddle said: "I've got to think about certain things. We've other things we'll look at and might experiment a little in midfield.
"It's unlikely we'll able to play the shape we've been working on so we'll have to change that as well, but these games are good for that."
Squad: Keller, Sullivan, Burch, Carr, Taricco, Perry, Mabizela, Gardner, Kelly, Bunjevcevic, Davies, Redknapp, Keane, Poyet, Doherty, Zamora, Jackson, Marney, Acimovic, Postiga, Ricketts.
Bobby Zamora and Mbulelo Mabizela are in the squad for Sporting Lisbon - but eight players miss out.