Gareth Bale will be rested as Harry Redknapp expects to make changes for the visit of Charlton in the FA Cup Third Round on Sunday.
The Welshman suffered a back spasm in the midweek defeat at Everton but the manager reports the injury is not thought to be serious.
And Gareth will not be the only regular sitting out this London derby as Harry looks to rotate his squad against the Addicks.
Jermain Defoe is available again after suspension and is expected to start, while there could also be places in the side for the likes of Vedran Corluka, Sandro and Niko Kranjcar.
Tom Huddlestone, Ledley King, Jamie O’Hara and Jonathan Woodgate remain sidelined through injury, while Younes Kaboul serves the final game of his three-match ban.