Steven Pienaar and William Gallas look set to start for the first time this season against Rubin Kazan on Thursday night.
The pair have been ruled out by injury so far in 2011-12 - Steven troubled by a groin problem, William has suffered calf strains - but both have made the trip to Russia for Matchday Four in the Europa League.
Giovani has not flown out with the squad after picking up a calf injury.
He joins Vedran Corluka (foot), Niko Kranjcar (thigh), Danny Rose (ankle), Tom Huddlestone (ankle) and Michael Dawson (Achilles) on the sidelines.
The squad is a mixture of experience and youth from the likes William and goalkeeper Carlo Cudicini to Second Year Academy trainees Jack Barthram and Kevin Stewart.
Heurelho Gomes, Seb Bassong, Jake Livermore, Jermain Defoe and Roman Pavlyuchenko, back in his home country, have all made the trip.