Kevin Bond has reported that 11 players are either doubtful or out of Saturday's clash against Blackburn at the Lane.
David Bentley (calf), Roman Pavlyuchenko (back) and Tom Huddlestone (ankle) are all doubtful after picking up injuries against Sunderland on Tuesday night.
"They are all struggling," reported assistant boss Kevin before training on Friday morning. "We'll have to wait until tomorrow to see how they all are.
"We've got a long injury list at the moment, 11 of the first-team squad either out or unlikely to be fit for the weekend.
"We're struggling on the injury front at the moment."
Aaron Lennon (hamstring) and Robbie Keane (ankle) have been out for the last matches against Bolton and Sunderland and remain out for Blackburn.
Better news sees Michael Dawson (ankle), Ledley King (groin) and Jermain Defoe (ankle) all progressing well in their rehabilitation.
Giovani (aductor strain) also remains out alongside long-term absentees Jamie O'Hara (back) and Jonathan Woodgate (groin).