The French international striker missed Wednesday night's FA Cup replay win against Stevenage after having fluid drained from his knee after Sunday's defeat against United.
Louis trained on Friday and is back in the frame to face the team he left for the Lane on January transfer window deadline day.
Harry Redknapp said William Gallas will also be available but Michael Dawson and Aaron Lennon miss out.
As we confirmed yesterday, Michael faces 10-12 weeks on the sidelines after rupturing ankle ligaments against Stevenage.
"It's such bad luck for him, he's fantastic player and a great guy, a real professional," said Harry. "It's a big loss for us.
"William should be okay, he's had calf injuries all season but hopefully he's back to fitness now.
"Ryan Nelsen came through the other night, I was pleased with him and we've got Younes and Ledley, hopefully we can keep Ledley fit.
"Aaron Lennon picked up a hamstring injury against Stevenage, he's not available. He shouldn't be out long. He's going for a scan today (Friday), but he doesn't feel too bad."