The injured trio are Fredi Kanoute (ankle), Simon Davies (thigh/hip) and Jamie Redknapp (knee).
Better news sees Anthony Gardner return from his one-match ban and Christian Ziege back in the squad.
Caretaker boss David said: "We've three players out of action at the moment - Fredi Kanoute, Simon Davies and Jamie Redknapp.
"Anthony Gardner is back from suspension and Christian Ziege has now played three reserves games so he'll come into our squad.
"Ledley King will train this morning and then we'll make a decision on him. He's doing fine though and I think he'll be an exceptional player.
"We hope Fredi's injury won't be as big a blow as it appears because of his excellent start. It means opportunities for either Bobby Zamora or Helder Postiga, three games in six days to start making their mark."
David Pleat reports that three players are out of Sunday's encounter against Middlesbrough and he will make a late decision on Ledley King.