The big defender picked up a knee injury in Wednesday's Carling Cup tie against Middlesbrough and was substituted at half-time.
Bobby Zamora is still struggling with a calf problem and the three longer-terms victims, Jamie Redknapp, Christian Ziege (both knee) and Simon Davies (hip), remained sidelined.
Acting boss David Pleat reported this morning: "We've got a couple of knocks from the other evening. Dean Richards had to leave the field at half-time and is doubtful, Darren Anderton is a little sore.
"It's a very similar squad and we'll perhaps add Mabizela and a couple of the youngsters like Blondel or Marney."
Dean Richards is the big doubt for tomorrow's Premiership clash against Manchester United at the Lane.