Sandro and William Gallas could return to action in Tuesday night's Carling Cup third round tie at Stoke.
Neither player has featured so far this season.
Sandro suffered a knee injury on international duty with Brazil at the Copa America in the summer while William is on the way back from a calf problem that struck early in pre-season.
"I'm hoping William Gallas may be okay to come back, we'll see how he is after training this morning," reported Harry Redknapp at Spurs Lodge on Monday.
"Sandro is also on his way back and I may get an hour out of him tomorrow. It would be great if I could get those two back playing again.
"Other than that it will be one or two of the younger players who have played recently and done well and one or two of the seniors players who didn't feature on Sunday."
The manager said he was likely to make a changes from the team that was so impressive against Liverpool on Sunday, but insisted he was after a win at Stoke, nothing less.
"We want to stay in the competition, we want to win and go all the way if we can," he said.
"We could have Sandro and William Gallas back, Pav needs another game, van der Vaart is back, Gomes, Bassong, Corluka - that's not a bad team, is it?
"One or two of the youngsters will get another chance as well."
Michael Dawson, Danny Rose, Steven Pienaar, Tom Huddlestone, Aaron Lennon all remain sidelined.