The 21-year-old only started full training on Monday after six weeks out with a foot problem but still managed a 10-minute substitute appearance against Newcastle United on Tuesday.
With Stephen Carr failing to shake off a nagging groin injury Young, his natural replacement, may start at wing-back in a five-man defence.
Gary Doherty should also hold onto his place in the centre of that defence after a fine performance and goal against Newcastle.
Boss George Graham is still without Carr, Maurico Taricco,Ben Thatcher (all groin), Steffen Freund (Achilles) and Steffen Iversen (knee).
He said: “It was nice to see Luke Young back on the bench again and playing the last 10 minutes of the game on Tuesday, Ben Thatcher is not quite ready yet, Mauricio Taricco is a way off, Steffen Iversen is a couple of months away and Steffen Freund could be back in training next week.
“It is improving slowly but it has been a major problem since I’ve been at the club, I haven’t solved the problem and I now know how the previous managers here felt.”
Leyton Orient are set to give YTS trainee Danny Hatcher his debut.
The 17-year-old has been confirmed as one of Tommy Taylor's substitutes for the London derby.
Taylor said: “Hatcher is like the boy (Tony) Cottee was when he was that age - he scores goals for fun and he'll be on the bench on Saturday and he's just turned 17.”
Central defender Simon Downer is another promising Orient youngster, who is almost certainly set to play a part and Taylor believes he can play at the highest level.
“Downer should play in the Premiership if the managers and scouts give him a chance. The boy's quick, he can pass the ball, he's a good defender and he reads the game ever so well and he's only 18.”
Taylor will be picking from a full strength squad apart from long-term knee injury victim Steve Castle, who is still sidelined.
Leading-scorer Carl Griffiths is expected to be partnered up front by Steve Watts although 19-year-old forward Kelechi Opara is also in the frame for a starting role.
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Luke Young may complete a rapid-fire return by starting against Leyton Orient in the FA Cup on Saturday.