The striker has a hamstring injury and joins Benoit Assou-Ekotto, Younes Kaboul (both knee), Jake Livermore (groin) and Scott Parker (Achilles) on the sidelines.
Better news sees goalkeeper Heurelho Gomes improving after his recent ankle problem.
Andre said on Wednesday: “Ade has been struggling with a muscle injury, so he will be out of the game.
“Benoit is still out, we’re waiting for the specialist to see his knee.
“Jake is making a good recovery from his groin strain, we’re looking to have him back in 10, 15 more days.
“Scotty is still a bit far off, maybe three weeks before he returns to first team training, so slowly making progress and Younes is out for some time.
“Gomes is now training at medium to high intensity with the team and will soon be back 100 per cent.”