The striker missed the first leg against Inter and Sunday's Premier League encounter at Liverpool after picking up a knee injury against Arsenal.
'Ade' partners Jermain Defoe up front as Andre Villas-Boas starts with a 4-4-2 system at the San Siro.
Andre has made four changes from Anfield - Ade's return is in affect for Gareth Bale, who is suspended, Brad Friedel replaces Hugo Lloris in goal and defensively, William Gallas starts for Michael Dawson and Kyle Naughton is back at left-back for Benoit Assou-Ekotto.
Good news also sees Aaron Lennon return from injury to take his place on the bench.
Spurs (4-4-2): Friedel; Walker, Gallas, Vertonghen, Naugghton; Dembele, Livermore, Parker, Sigurdsson; Adebayor, Defoe. Subs: Lloris, Assou-Ekotto, Caulker, Carroll, Holtby, Huddlestone, Lennon.
Remember, we kick-off at 6pm UK time, 7pm local.