Michael Dawson also returns and partners Caulker in central defence, with Jan Vertonghen switching to left-back. Benoit Assou-Ekotto pushes forward to left midfield in place of Jake Livermore.
The other changes see Hugo Lloris back for Brad Friedel in goal and Gareth Bale back up front alongside Emmanuel Adebayor.
Spurs: Lloris; Naughton, Caulker, Dawson, Vertonghen; Sigurdsson, Dembele, Parker, Assou-Ekotto; Adebayor, Bale. Subs: Friedel, Walker, Carroll, Holtby, Livermore, Defoe, Dempsey.