Harry Redknapp reports that Giovani and Roman Pavlyuchenko are doubtful ahead of Wednesday night's Europa League clash against PAOK.
Giovani has a groin strain and Roman a knee injury as we prepare for Matchday Five in the competition. We complete the group stages at Shamrock Rovers next month.
"They are both struggling," said Harry before training on Wednesday.
"We have a great squad and looking at tomorrow night, we'll make changes and the players who play will all be of very high-quality, in my opinion."
Carlo Cudicini, William Gallas, Seb Bassong, Steven Pienaar, Giovani, Roman and Jermain Defoe all started in our last group match against Rubin Kazan.
Luka Modric has returned to training after illness ruled him out of Saturday's win at West Brom.
Niko Kranjcar (thigh), Danny Rose (ankle), Michael Dawson (Achilles) and Tom Huddlestone (ankle) remain out.