Alton Thelwell (20), Ledley King (20), Matthew Etherington (19), Simon Davies (21), Gary Doherty (20) and Anthony Gardner (20) are all in George Graham’s squad for the trip to Chelsea.
Steffen Freund has recovered from a bout of flu while Luke Young is back in the frame after gastroenteritis forced him out against Derby County last week.
But the other side of the coin is that we’ll be without Sol Campbell (shoulder), Oyvind Leonhardsen (pictured right, hamstring), Steffen Iversen (knee), Mauricio Taricco (groin) and Chris Armstrong (groin, hamstring).
In-form Willem Korsten, who hit four goals for the reserves in midweek, is also named in the squad.
Chelsea boss Claudio Ranieri will be tempted to stick with the side that routed Coventry 6-1 at Stamford Bridge last weekend.
Graeme Le Saux starts a three-match suspension following his sending off at Sunderland two weeks ago, while Mario Stanic, who is recovering from surgery on his knee, will miss the London derby.
Jimmy Floyd Hasselbaink, who scored four times in last week's defeat of the Sky Blues, will be gunning for more goals.
Spurs squad: Sullivan, Walker, Carr, Freund, Perry, Anderton, Sherwood, Ferdinand, Rebrov, Korsten, Thatcher, Young, Clemence, King, Etherington, Davies, Gardner, Dominguez, Thelwell, Vega, Doherty.
Chelsea squad: De Goey, Panucci, Melchiot, Desailly, Leboeuf, Bogarde, Babayaro, Ferrer, Dalla Bona, Morris, Wise, Hasselbaink, Jokanovic, Poyet, Flo, Zola, Gudjohnsen, Aleksidze, Cudicini.
Youth may get its chance at Stamford Bridge on Saturday.