Darren Anderton, Simon Davies and Dean Richards will be absent for the trip to Southampton on Saturday.
Richards has been suffering with an ear infection that has restricted his training this week, while Darren is out with an Achilles injury and Simon a shin problem. Mauricio Taricco is doubtful for the St Mary's encounter with a hip injury sustained at Manchester United last week.
"I would have to say lucky with injuries for a while now," considered Chris Hughton of the fact that only three of the squad are certainly unavailable for the game. "We have missed key players at times, Darren, Dean and Simon are key players for us, but we have done fairly well for a while now."
For Southampton, defender Michael Svensson is rated extremely doubtful with a calf strain, while Graeme Le Saux (hamstring) and Matt Oakley (cruciate) are definitely out. Striker Brett Ormerod could make the bench after returning to training following an ear infection.