Harry Redknapp reports that Luka Modric and Vedran Corluka are both fit and back in the frame to face West Ham on Saturday.
Luka has trained this week after picking up a leg injury at West Brom on September 11.
Vedran suffered a back problem last week forcing him out of the games against Wolves and Arsenal, but the defender returned to training this morning (Friday, September 24).
Ledley King and Rafael van der Vaart are also available for selection and Harry admitted he now has decisions to make with what is always a tough test in the Premier League at Upton Park followed by FC Twente in the Champions League at the Lane on Wednesday.
"Luka is fit to play and could play, so do I take a chance tomorrow (at West Ham) or save him for Wednesday?" said Harry.
"They are all big games and it's a balancing act at the moment.
"Rafael is fine but Ledley had a little swelling in his knee, so we'll wait and see on him."
Harry also reported that Benoit Assou-Ekotto picked up a slight knee problem during Wednesday night's Carling Cup tie against Arsenal.
Meanwhile, goalkeeper Heurelho Gomes is closing in on a return after suffering a groin injury in the first half against Wigan on August 28.
"He's back in training but just feels he's a little way away," added Harry. "He could be available on Wednesday but Carlo has done great for us, so it's not too much of a problem."