Younes Kaboul is the latest doubt after picking up a thigh problem playing for France Under-21s against Wales on Tuesday.
He's joins a defensive list that inclues Ledley King, Benoit Assou-Ekotto (both knee), Anthony Gardner and Ricardo Rocha (both ankle). First team coach Gus Poyet has also indicated that Gareth Bale (foot) remains still a doubt for this weekend.
Steed Malbranque is also a question mark for Upton Park with the ankle injury he sustained last time out against Wigan.
Juande Ramos is still without a number of defenders as he prepares the team for Sunday's clash at West Ham.