The flying wing-back picked up the problem against West Ham last week and is expected to be sidelined for up to three weeks.
Ledley King (Achilles) and Dean Richards (knee) remain out alongside Les Ferdinand, Steve Carr, Steffen Freund, Goran Bunjevcevic and Alton Thelwell.
At least Mauricio Taricco is available again after his five-match suspension.
Boss Glenn Hoddle said: "The downside of international week was Christian.
"He did that against West Ham and that's when why had to take him off. The ankle locked and there was a very small floating piece of cartilage or bone that has got trapped in there.
"It was a simple operation, nothing drastic, but he'll be out for two or three weeks.
"Ledley is still having treatment and Deano's knee is improving by the day but he's not ready yet. So it's the same story and we go there with 16 or 17 fit players."
Christian Ziege is out of Saturday's trip to Bolton after undergoing surgery in Germany earlier this week.