Hugo has trained again this week after picking up a slight knee injury in France's World Cup qualifier against Spain on March 26 that ruled him out of Saturday's win at Swansea.
Clint Dempsey also comes back into the frame after his World Cup qualifying exploits for the USA but Jermain is sidelined by a muscle injury.
"Hugo is back in training, Clint is also fully involved after his international fixtures but Jermain is a new injury blow," reported Andre after training on Wednesday.
"Jermain is likely to miss the next two games against Basel and Everton but has a small chance for the second leg against Basel."
Andre also said that Tom Carroll (hamstring) remains out alongside longer-term Younes Kaboul and Sandro.