With Paolo Di Canio almost certainly out for a few games with strained medial knee ligament, Defoe is set to lead the Hammers attack with Freddie Kanoute.
Anthony feels that the young striker warrants plenty of attention from our back line.
"Jermain Defoe will probably play. Sharp, very sharp, he's been playing in and out really, but has made great progress since last season when he was with Bournemouth.
"He's been playing well for the under-21s and he'll be dangerous - I'll have to keep an eye on him."
The former Port Vale man says that Defoe's season-long stay at Bournemouth would have been of great benefit to the striker in preparation for the leap to the Premiership.
"I think it will have done him a lot of good. It's getting league experience and confidence mainly. For him, scoring goals and getting confidence playing at a lower level - it sets you up with a know-how of the game to step in at a higher level.
"He's pretty quick and we're going to have to be on our toes and alert to him if he starts on Saturday."
Anthony Gardner has singled out England under-21 striker Jermain Defoe as a likely threat ahead of West Ham's visit to the Lane on Saturday.