The young midfielder has been in fine form for the reserves this season and bagged two goals in the 3-3 draw against Watford on Wednesday night.
Ledley is back from the hamstring problem he sustained against Chelsea in September but Anthony Gardner misses out through suspension.
Jamie Redknapp, Simon Davies, Christian Ziege and Kazu Toda - all coming back from injury - are not in the squad.
Squad: Keller, Burch, Carr, Richards, King, Doherty, Bunjevcevic, Mabizela, Taricco, Anderton, Ricketts, Poyet, Konchesky, Dalmat, Jackson, Keane, Kanoute, Zamora.
John Jackson joins the returning Ledley King in the squad for Sunday's Premiership clash at Leicester City.