The midfielder hasn't featured for us since the draw against Everton on August 29 but returned for Algerian duty against Tanzania in World Cup qualifying on Tuesday, only to pick up an ankle injury.
Mauricio Pochettino reported: "I think everyone knows that Nabil got a bad tackle in the first minute of Algeria’s game against Tanzania and he's not 100%. We need to be sure. He’ll work hard to get back as soon as possible but it’s difficult for him on Sunday."
Erik Lamela serves a one-match suspension after receiving his fifth yellow card of the season at Arsenal last time out.
Nacer Chadli (ankle) and Alex Pritchard (ankle) remain sidelined.