Eric Dier gave us the lead six minutes before the interval with a glancing header from a corner in a half which was mostly one-way traffic in our favour, but two substitutes turned the game around for the visitors. Aleksandar Mitrovic poked home from close range to level the scores with 16 minutes remaining before Ayoze Perez hit a 93rd-minute winner.
The defeat was our first in the league in 14 matches and means we stay in fifth place in the table.
There was just one change to the side which drew with West Brom last weekend, Tom Carroll rewarded for his performance and goal against Monaco three days ago by coming in at the expense of Mousa Dembele. It was Academy product Carroll’s first Premier League start in our colours.
We were immediately on the offensive and Harry Kane tested Rob Elliot inside the first minute with a low drive towards the near post, while the visitors were a touch unfortunate four minutes later when Siem De Jong cut inside and let fly but his goalbound shot hit Papiss Cisse and went out for a goal-kick.
It was certainly an open contest even though the majority of the opportunities were falling our way. Erik Lamela saw a shot blocked and in the next phase of play, Dier was strong in the tackle to win back possession but then dragged his effort wide.
On 18 minutes, Christian Eriksen ignored the overlapping run from Kyle Walker and tried his luck from distance, his shot was deflected behind for a corner and when he received the ball again after the set piece was cleared, his second effort was a couple of yards wide.
The visitors had another sight of goal on 33 minutes when Georginio Wijnaldum collected Elliot’s long goal-kick and beat Walker to the ball, he back-heeled to the supporting Paul Dummett who delivered a tempting cross which Cisse headed two yards wide.
We were then denied a couple of times by two fine saves from the Magpies keeper. First, Carroll found Danny Rose with a pass inside Daryl Janmaat, the full-back cut the ball back to Lamela on the edge of the area and he clipped a first time shot towards the top corner which Elliot palmed away at full stretch.
And two minutes later, Lamela latched onto Kane’s flick-on and held off two challenges before poking a rising shot which Elliot tipped over. However, from the corner, Eriksen got his delivery spot on and Dier steamed in with a near post flicked header which flew into the top corner.
It was almost 2-0 on the stroke of half-time when Eriksen’s shot was blocked but the ball fell kindly to Rose in the left channel inside the area and he fizzed a low centre to the back post which Kane just failed to reach sliding in.
That brought the first half to a conclusion but we were just as dangerous at the start of the second period, winning a free-kick in the opening minutes. Lamela led the break out from the back and found Walker surging forwards, he squared to Dele Alli 20 yards out who was upended as he shaped to shoot. Eriksen’s set-piece, however, was straight into the wall.
The visitors carved out a great chance of their own on 50 minutes when Moussa Sissoko played a pass in to Cisse in the left channel of the area but he dragged his low shot wide of the far post.
And the same pair combined 11 minutes later, but this time there was no power on Cisse’s header and it was comfortable for Hugo Lloris.
Our first change of the afternoon saw Heung-Min Son replace Carroll with 22 minutes remaining and moments after his introduction, we won another free-kick in a dangerous position but Eriksen’s effort was straight at Elliot. The keeper was there again in the 72nd minute, making a sprawling save to his left to deny the Dane from distance.
We had lost a bit of our fluency at that stage with passes going astray and the visitors took full advantage with the equalising goal. Rose was penalised for handball near the byline, Colback delivered a deep free-kick which Fabricio Coloccini headed back into the danger zone, Chancel Mbemba stooped to head goalwards and substitute Mitrovic got the final touch almost standing on the goal-line.
Newcastle were starting to cause problems on the counter and almost snatched a second when Sissoko burst clear down the right and sent over a low cross which Toby Alderweireld had to cut out to prevent a certain tap in for Perez.
As the game entered the closing 10 minutes we started to probe again, Son having an opportunity 25 yards out but he fired well over under pressure, while Vurnon Anita took the sting out of Alli’s shot from a similar distance and the ball landed in the arms of Elliot.
But the Magpies were always a threat and when Sissoko again got clear down the right, his low cross just evaded Mitrovic at the far post. But when they broke again deep in stoppage time, they grabbed the winner. Wijnaldum lifted the ball forwards, Mitrovic headed on to Perez who shrugged off Jan Vertonghen and hit a first time effort under Lloris and into the net.
Spurs (4-2-3-1): Lloris, Walker, Alderweireld, Vertonghen, Rose, Dier, Carroll (Son 69), Lamela (Chadli 86), Alli, Eriksen, Kane. Substitutes (not used): Vorm, Trippier, Davies, Bentaleb, Onomah.
Newcastle (4-4-2): Elliot, Dummett, Mbemba, Coloccini, Janmaat, Wijnaldum, Colback, Anita (Gouffran 90), Sissoko, Cisse (Mitrovic 72), De Jong (Perez 63). Substitutes (not used): Darlow, Thauvin, Sterry, Mbabu.
Goals: Spurs – Dier 39; Newcastle – Mitrovic 74, Perez 90+3.
Yellow cards: Spurs – Carroll, Rose; Newcastle – Colback, Perez.
Referee: Roger East.