The FA Women's Premier League encounter represents the fourth time the teams have met this season and Spurs hold a 100 per cent record in three contrasting matches so far.
The first match in the FAWPL at Cheshunt saw Spurs dominate yet forced to recover from a late equaliser to score a last-minute winner.
Spurs then coasted home 5-0 in the Ryman Cup semi-final in January before a third meeting, this time in the Capital Cup quarter-final, went all the way to penalties - Spurs came home 7-6 in the shoot-out.
"The players are excited, of course and it's a fantastic opportunity for us," said manager Karen.
"We're comfortable in the table at the moment so I will tell the players that there is no pressure on them and the aim is to go out and perform on the big stage.
"The important thing for us is to put in that performance and not get swept away by it all. We can all enjoy it, but we want to win the game and there is a real determination about the team to do that.
"We've only lost once in 2016 to a WSL side (Villa in the FA Cup) and we all want to keep that momentum."
Spurs reached the semi-final of the League Cup with a fine 1-0 win against Brighton on Sunday - report here...