It's an intriguing opener for the team as they bid to follow up their best-ever season last term.
Spurs reached three cup finals and landed the spoils in the Ryman Cup and the national FAWPL Cup - the greatest success in the club's 30-year history.
As they chased cup glory on four fronts, there was also a commendable sixth-placed finish in the FAWPL, but a finish manager Karen Hills is determined to improve on - with her sights set on going better than the club's best of fifth in 2014-15.
That starts against a Swindon team promoted as champions from FAWPL South-West having won 15 and lost just one of their 18 matches in 2015-16.
The teams met in January when Spurs stormed into a 4-0 lead by half-time on their way to a 4-1 win in the FA Cup.
"We can't wait to get started," said Karen. "The players have been back in training for a while and there is a hunger there to push on again after last season.
"Swindon is an interesting start for us. We'll get a picture of where they are after winning their title last season. We know from the FA Cup tie that they have some quality players and they will no doubt look to sign new players after being promoted.
"We're looking for consistency in the league this time around and we'll be looking to make a positive start."
FA WOMEN'S PREMIER LEAGUE SOUTH FIXTURES 2016-17
Aug 28 - Swindon Town H
Sep 11 - Crystal Palace A (Bromley FC)
Sep 14 - QPR A (Uxbridge FC) - 7.45pm
Sep 18 - Lewes A (Lewes FC)
Oct 2 - C&K Basildon H
Oct 5 - QPR H - 7.45pm
Oct 9 - Forest Green Rovers A (Slimbridge AFC)
Oct 16 - Cardiff City H
Oct 23 - Portsmouth H
Oct 30 - C&K Basildon A (Canvey Island FC)
Nov 6 - Crystal Palace H
Nov 13 - Forest Green Rovers H
Nov 20 - Coventry United A (Park Meadow)
Nov 27 - Swindon Town A (Shrivenham FC)
Dec 11 - Lewes H
Jan 8 - Coventry United H
Jan 15 - Charlton Athletic H
Feb 5 - Cardiff City A (CCB Centre for Sporting Excellence)
Feb 26 - Portsmouth A (Gosport Borough FC)
Mar 12 - Charlton A (Sporting Club Thamesmead)
Mar 26 - West Ham H
May 14 - West Ham A (AFC Hornchurch)
Home matches at Cheshunt FC
All kick-offs 2pm unless stated otherwise