The tour will take place from July 23-30 and will include matches in Durban and Cape Town.
South African Champions Orlando Pirates provide the opposition on Saturday July 26 with a 4pm kick-off before the team head to Cape Town to take on Kaizer Chiefs on Tuesday July 29.
The trip will also help South Africa's 2010 World Cup bid and highlight the country's infrastructure and organisational capacity.
Glenn Hoddle is delighted to incorporate such a prestigious overseas tour in his pre-season schedule.
"We have many good friends and supporters in South Africa and look forward to returning to a country that is always passionate about its football.
"We will be looking for a strenuous work-out as part of our build-up to the new English season and know that the emergence of South African football will guarantee the kind of test that we need. It represents the perfect preparation for us.
"We are very happy to support South Africa in their World Cup bid and if tours like this can help their cause then we are pleased to play our part."
The first team squad return to training this week to begin their pre-season preparations - the highlight of which is a two-match trip to South Africa later this month.