We asked for memories of opening day and trips to Old Trafford.
Here's what our supporters had to say...
Paul Hutchens, Kernow (Conwall) Spurs
"My biggest memory of a first game of the season would be the 1994-95 season away at Sheffield Wednesday, a 4-3 win and Jurgen Klinsmann scoring on his debut with the iconic 'dive' celebration. This was copied on playing fields for months at my school and started a roller-coaster season. Memories of Old Trafford have mostly been disappointing ones. Kernow Spurs went to the game last season and are hoping for a better result this year. Although a memory that does stick out is Pedro Mendes' long range 'goal' that wasn't given, despite it being a couple of clear yards over the line!"
Des Conway, Athlone Spurs
"Jurgen Klinsmann's debut versus Sheffield Wednesday was a cracking game. Gareth Bale;s goal at Old Trafford in 2012 was one of the defining moments of what was to come from one of the best players I have ever seen in lilywhite."
Barry Graham, Glasgow Spurs
"A couple of opening days stick in my mind - the win at West Ham last season because it was a late, late winner by Dier when we were down to 10 men and hadn't played particularly well and the victory at home to Liverpool in 2009 - and especially that screamer from Assou-Ekotto - as it set the tone for that great season in which we qualified for the Champions League. For years Old Trafford was just a write-off for us, so the 3-2 win there in September 2012 was hugely symbolic and wonderfully unexpected. There was the joy of Dempsey making it 3-1 early in the second half, then despair as United instantly pulled one back. I was convinced then that United were bound to not just equalise, but win it, given there was so much time left. But somehow we held on for a famous win."