For a start, there were Spurs debut for summer recruits Roberto Soldado and Paulinho, plus a home debut for Nacer Chadli.
Soldado then scored on his first appearance, a confident penalty strike after Danny Rose was upended in the 28th minute.
Espanyol levelled through David Lopez’s header a minute before the break but it was soon time for a double dose of good news as first Younes Kaboul and then Sandro returned from long-term injuries.
Kaboul joined the action as a half-time substitute – his first senior action since August last year – before Sandro’s arrival for Paulinho on the hour, his return after suffering a serious knee injury in January.
“There were very positive aspects for all the team,” said Andre.
“Following on from Monaco, it was a great performance, great attitude, good combinations in the first half, some really interesting football.
“The result didn’t go with the performance. I think we deserved better and I’m extremely happy with everyone.
“It was the first time at White Hart Lane for the new signings, with that intensity, the fans were pushing us on and they did well, Nacer, Paulinho and Soldado.
“We saw great signs from Kaboul and Sandro coming back, Michael Dawson played 90 minutes after an injury. There were lots and lots of positives. I just hope we can translate it into three points against Palace next week.”