The midfielder impressed again, this time starting as one of the forward three as we toppled Villa 3-1 at the Lane to make it 10 unbeaten in the Premier League.
Mousa paved the way to victory with the opener on three minutes - his second goal in as many games in the Premier League. He latched onto Danny Rose's pass down the left, got the better of Ciaran Clark and fired low past Brad Guzan.
It's the second home match on the trot that Mousa has taken the fans' honours after his outstanding display against Liverpool.
In a close vote across Twitter, Facebook and the Match Centre here on tottenhamhotspur,com, Mousa's fellow goalscorer Dele Alli - who won Sky Sports' MOTM award - was second and Eric Dier third.
MAN OF THE MATCH - VILLA HOME
Mousa Dembele - 45%
Dele Alli - 32.6%
Eric Dier - 22.4%
Thanks for voting!